Acharya Nagarjuna University

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Dr. K.R.S. Sambasiva Rao
DOB:  8/15/1958
DOJ:  8/16/1988
Title of PhD Thesis
Studies on the toxic impact of carbonyl and phentaoate on some metabolic aspects of a moral, Channa punctuates (block)-A synergistic study
University from which PhD received S.V.University, Tirupathi
Major / Minor Research Projects Conducted Projects Ongoing :
UGC Project on Prostrate Specific antigen A New Dignostic Marker for Breast Cancer

Completed Projects :
DBT Project Studies on Isolation, Cloning and production of Industrially important Cold adaptive Enzymes from Marine Extremophiles

UGC Project Analysis and production of a constructed multifunctional chimeric thrombolytic therapeutic molecule

DST Project Biodiversity of subterranean ground-waters of India, with special reference to Copepoda and Bathynellacea (as Co-investigator)

DBT project Neem seed powder unit and Neem trees plantation and Maintenance to increase the earnings of SC/ST population in Tenali Mandal (as Co-investigator)

Completed one UGC-Minor Research Project Studies on Predator-Prey relationship in Fish culture ponds

Completed one UGC-Minor Research Studies on anti-oxidative mechanisms in toxicity induced animals

Projects completed with Private industry : One Project has been undertaken with Aqua Prime, Nellore in investigating the diagnosis and control of ADS

One project undertaken with Shrimp Care Centre, Nellore in investigating genetic variants of WSSV
Areas of Research Interest 33 Years of Research Experience in the fields Environmental Toxicology & Physiology,
Aquaculture Biotechnology and Fermentation Technology

- During the stay at DNA Sequencing Core Facility, Emory University, Atlanta, USA research
work has been carried out in the fields of Gene Chip Technology and DNA Sequencing
during December 1999 to April 2000

- During the stay at Wood Biotechnology Divin, Georg-Augusta University of Gottingen,
worked on cloning and expression of laccase genes in fungal species Coprinus
cenereus during May to August, 2003

- During the stay at Dept. of Physiology and Medicine, Virginia Commonwealth University,
USA, worked on Molecular Signal Transduction Mechanisms in smooth muscles during
April to July, 2005

- During the stay at INDICASAT, Republic of Panama, worked Neurotoxicology and Brain
disorders during 2010 to 2013 as Adjunct faculty

Presently continuing research in the field of Biotechnology relating to Molecular Biology, Environmental Biotechnology, Fermentation Technology and Aquaculture
No of PhDs Guided 21  
No. of MPhils Guided 20  
Academic Achievements 25 years of teaching and research experience. Published more than 150 research papers and 20 books. Guided 20 M.Phil. and 21 Ph.D. students. Participated in several national and international conferences. Worked as a Visiting Scientist at Emory University, Atlanta, USA on DNA chip technology. . Worked as a visiting scientist at George-Augusta University of Gottingen, Germany and worked on cloning and expression of laccase genes. Visited Virginia Commonwealth University, USA and worked on signal transduction in smooth muscles. Visited Australia for attending an international conference and visited University of Adelaide and CSIRO. Adjunt Professor at INDICASAT, Republic of Panama since during 2010 to 2014. Handled several research Projects and organized national conferences and workshops.  
No. of Books Published 20  
No. of research articles published 150  
National Journals Editorial Activities:
- Editorial board member of Journal of Applied Biology
- Executive member for ISCAP and member of editorial group
- Member of Editorial group of African Journal of Biotechnology -Member of Iranian Journal of
- Editor Current Trends in Biotechnology and Pharmacy
- Editorial Member, J. of Pharmacology and Toxicology
- Editorial board member of Research Journal of Biotechnology

Recent Publications:
K.R.S.Sambasiva Rao, N.K.Tripathy, Y. Mahalaxmi, R.S.Prakasham and D.Srinivasa Rao, Improved Production of Laccase and Peroxidase-Free Tyrosinase in Streptomyces antibioticus, BioProcessing Journal, 13(2): 46-54 (2013)

K K Pulicherla, Anmol Kumar, G S Gadupudi, Seetharam Kotra, K R S Sambasiva Rao. In Vitro Characterization of a Multifunctional Staphylokinase Variant with Reduced Reocclusion, Produced from Salt Inducible E. coli GJ1158. Biomed Research International. Volume 2013, Article ID 297305, (2013)

KK Pulicherla, P Suresh Kumar, K. Manideep, V.P.B. Rekha, Mrinmoy Ghosh and K.R.S. Sambasiva Rao Statistical approach for the enhanced production of cold active -galactosidase from Thalassospira frigidphilosprofundus: A novel marine psychrophile from deep waters of Bay of Bengal. Preparative Biochemistry and Biotechnology 43:8, 766-780 (2013)

Vemuri Praveen Kumar, Veeravalli Suryanarayana, Poda Sudhakar and Krothapalli Raja Surya Sambasiva Rao. Cloning, Expression and Purification of Recombinant Human Galectin-3 by Using pPUZZLE Shuttle Vector in Bacterial Strain (DE3) Host System. Advanced Biotech. 13(1): 9-12 (2013).

Chandrasekhar Gurramkonda, Sheikh M. Talha, Satheesh Kumar Gudi, Venkateswara Rao Gogineni and Krothapalli Raja Surya Sambasiva Rao. Fed-batch cultivation of Escherichia coli expressed designer hepatitis C virus diagnostic intermediate and its Evaluation. Biotechnology and Applied Biochemistry, 59(6): 437-444 (2012)

K.R.S. Sambasiva Rao, N.K. Tripathy, Y. Mahalaxmi and R. S. Prakasham, Biochemical Characterization and Identification of Extracellular Tyrosinase Biosynthesis in Streptomyces antibioticus, Journal of Biochemistry and Bioinformatics, 2(4) 90-92 (2012)

Sambasiva Rao, K.R.S., N.K.Tripathy, Y.Mahalakshmi and R.S.Prakasham. Laccase- and Peroxidase-Free Tyrosinase Production by Isolated Microbial Strain. J. Microbiol. Biotechnol., 22(2): 207-214 (2012)

Sunila Mahavadi, Jiean Huang, Vimolpal Sriwai, Krothapalli R.S.S.Rao, Karnam S. Murthy, Cross-regulation OF VAPC2 receptor Internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2, Regulatory Peptides139:109-114 (2007)

RKPatel, K.M. Singh, KJ Soni, J.B. Chauhan, KRS Samba Siva rao, G.Venkateswara Rao and K.R..S. Samba Siva Rao, Screening of Dairy Bulls for Weaver syndrome in India Current Trends in Biotechnology and Pharmacy, 2(1) 192-197(2008) Vol 5(25)

Ch.Madhu Babu, R. Chakrabarthi and K.R.S.Sambasiva Rao, Enzyanatic isolation of corotonoid protein complex from shrimp heads waste and its use as a source of Corticoids, LWT Food Science and Technology 41(2): 227-235/(2008).

Raghu Gangula, R. Chakrabarthi and K.R.S.Sambasiva Rao, Distribution of proteolytic activity in the different protein fraction of tropical shrimp waste, Food Biotechnology,/22(1):18-30 (2008).

K.Ananda Krishna, G.Venkateswara Rao and KRS Sambasiva Rao, Chaperonin GroEL structure and Reaction Cycle, Current Protein Peptide Science 8:418-425 (2007)

K.Anand Krishna, G.V.Rao and K.R.Sambasiva Rao Stem cell based therapy for the treatment of type I Diabetics mellitus, Regenerative Medicine, 2(2): 171-177 (2007)

Membership in Professional bodies :
- Life Member, Indian Science Congress Association
- Life member, Asian Fisheries Society, Philippines
- Life member, Asian Fisheries Society, Indian branch, Mangalore
- Life member, Association for Indian Society for Comparative Animal Physiologists,
Tirupathi, India
- Life member, National Oil Palm Research Association, India
- Life Member, Indian Association for Nuclear Chemist and Allied Sciences (IANCAS),
Mumbai, India
- Life member, Biotech Research Society of India, Trivandrum, India
- Life member Indian Society of Applied Biology, Lucknow, India
- General Secretary, Association of Biotechnology & Pharmacy, Guntur, India

Other positions held :
- Chairman, UG BOS in Biotechnology, Acharya Nagarjuna University
- Member BOS in Engg. Biotechnology, AN University
- Member, PG Board of Studies in Biotechnology, SWIMS, Tirupathi
- Member, PG Board of Studies in Biotechnology, Berhampur University, Orissa
- Chairman, PG BOS in Biotechnology, MG University, Nalgonda
- Chairman, PG BOS in Zoology, VS University, Nellore
- Member, PG BOS in Biotechnology, SK University, Anantapur
- Member, PG Board of Studies in Biotechnology, Rayalaseema University, Karnool
- Member, PG BOS in Animal Biotechnology, SV University, Tirupathi
- Member, PG BOS in Biotechnology, Padmavathi Mahila University
- Member, UG Board of studies in Biotechnology, Andhra Loyola college,
- Member PG Board of studies in S.K.University,Ananatpur
- Montessori Mahila college, JMJ college and VSR college
- Member, BOS in KLC College of engineering for BTech Biotechnology
Research Collaboration with the faculty of foreign Universities Having research collaboration with Virginia Commonwealth University, Richmond, USA in the area of signal transduction in smooth muscles. Research collaboration with George. Augusta Gottingen University, Germany in the area of Fungal Biotechnology. Research collaboration in Neurotoxicology area with INDICASAT, Republic of Panama  


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